Nuclear lamins were initially identified as the major components of the nuclear lamina a proteinaceous layer found at the interface between chromatin and the inner nuclear membrane fawcett 1966 due to their position at the periphery of the nucleus lamins were originally proposed to support the nuclear envelope and provide anchorage sites for chromatin. Left collagen and lamin a levels scale with e consistent with matching tissue stress to nuclear mechanics right matrix stiffness in tissue culture increases cell tension and stabilizes lamin a regulating its own transcription and that of stress fiber genes enhancing. Tissue micromechanics correlate with abundance of collagens and nuclear lamins which influence cell differentiation.
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