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The cancer stem cell concept of cancer is an emerging paradigm with accumulating supporting evidence in recent years.
Colorectal cancer stem cell markers. This marker has been investigated to better understand the characteristics and functions of cancer stem cells. Colorectal cancer crc is the second most common cancer in women and the third most common in men. 1 hunan key laboratory of translational radiation. Cancer stem cells in progression of colorectal cancer.
There has been accumulating evidence in support of the cancer stem cell csc concept of cancer which proposes that cscs are central in the initiation of cancer. Cancer stem cells in colorectal cancer are characterised by their expression of multiple markers. Adenocarcinoma accounts for 90 of crc cases. This topic remains highly controversial due to the lack of widely accepted specific molecular markers.
This article reviews the current knowledge in these cancer stem cell markers and future directions of this field of research. Colorectal cancer stem cells cr cscs markers identification and localization of cr cscs through different markers is difficult as well as highlighting different pathways disrupted in crc.
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